文献详情
RETRACTED: LncRNA DLEU1 accelerates the malignant progression of clear cell renal cell carcinoma via regulating miRNA-194-5p (Retracted article. See vol. 24, pg. 10920, 2020)
作者He, G.Z.[1];Yu, S.Y.[2];Zhou, Q.P.[3];Chen, M.L.[4];Zhang, Y.W.[5];Zheng, Y.[6];Zhang, Z.B.[7];Han, Z.Y.[8];Yu, J.[9]
文献类型期刊
机构
通讯作者Yu, J (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing, Peoples R China.
期刊名称EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES影响因子和分区
2019
23
24
页码范围10691-10698
增刊正刊
收录情况SCI(E)(WOS:000503991300016)  
期刊等级
百度学术RETRACTED: LncRNA DLEU1 accelerates the malignant progression of clear cell renal cell carcinoma via regulating miRNA-194-5p (Retracted article. See vol. 24, pg. 10920, 2020)
语言外文
ISSN1128-3602
DOI10.26355/eurrev_201912_19768
被引频次4
人气指数39
浏览次数39
基金National Key Research and Digital Diagnosis and Treatment Equipment Research and Development Project [2017YFC0112000]
关键词LncRNA DLEU1; MiRNA-194-5p; Clear cell renal cell carcinoma (CcRCC); Metastasis
摘要OBJECTIVE: The aim of this study was to illustrate the role of long non-coding RNA (lncRNA) DLEU1 in regulating the malignant progression of clear cell renal cell carcinoma (ccRCC) by targeting microRNA-194-5p (miRNA-194-5p). PATIENTS AND METHODS: DLEU1 expression level in ccRCC tissues and para-cancerous tissues was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between DLEU1 expression and pathological indexes of ceRCC patients was assessed. After the silence of DLUE1, the proliferative and migratory abilities of ACHN and 786-O cells were evaluated. Furthermore, Dual-Luciferase reporter gene assay and rescue experiments were conducted to identify the role of DLEU1/miRNA-194-5p in regulating the ccRCC progression in vitro. RESULTS: DLEU1 expression was markedly up-regulated in ccRCC tissues when compared with para-cancerous tissues. The rates of lymphatic metastasis and distant metastasis in ccRCC patients with a high level of DLEU1 were significantly higher, whereas the prognosis was significantly worse. Transfection of si-DLEU1 remarkably attenuated proliferative and migratory abilities of ACHN and 786-0 cells. MiRNA-194-5p was identified as the target gene of DLEU1. In addition, the knockdown of miRNA-194-5p could reverse the regulatory effect of DLEU1 on the proliferative and metastatic abilities of ccRCC. CONCLUSIONS: DLEU1 is closely related to lymphatic metastasis, distant metastasis, and poor prognosis of ccRCC. It aggravates the progression of ccRCC by targeting miRNA-194-5p.
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LncRNA DLEU1 accelerates the malignant progression of clear cell renal cell carcinoma via regulating miRNA-194-5p.

He, G.Z., Yu, S.Y., Zhou, Q.P., et al. .EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. 2019, 23(24), 10691-10698.

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